Acoustic tools detect vibrating microbubbles, act as oxygen sensors
SEATTLE, November 29, 2021 – Blood carries vital oxygen through our circulation system to muscles and organs. Acoustic tools can create small bubbles in our blood, capable of changing in response to oxygen and signifying oxygen levels.
During the 181st Meeting of the Acoustical Society of America, which will be held Nov. 29 to Dec. 3, Shashank Sirsi, from the University of Texas at Dallas, will discuss how circulating microbubbles can be used to measure oxygen levels. The talk, “Hemoglobin Microbubbles for In Vivo Blood Oxygen Level Dependent Imaging: Boldly Moving Beyond MRI,” will take place Monday, Nov. 29, at 11:25 a.m. Eastern U.S.
Microbubbles are smaller than one hundredth of a millimeter in diameter and can be made by emulsifying lipids or proteins with a gas. The gas filling of microbubbles causes them to oscillate and vibrate when ultrasound is applied, scattering energy and generating an acoustic response that can be detected by a clinical ultrasound scanner. They are routinely used in medical imaging to provide greater contrast in tissue.
Hemoglobin, the protein that gives red blood cells their signature color, will form a stable shell around microbubbles. It then continues to carry out its typical role of binding and releasing oxygen in blood.
Sirsi and his team developed microbubbles to acoustically detect blood oxygen levels, since the microbubble shells are altered by structural hemoglobin changes in response to oxygen. The hemoglobin shell is continually responsive to oxygen after surrounding the bubble and has been optimized to perform in living organisms’ circulation.
“When oxygen binds to hemoglobin, there are structural changes in the protein that change the mechanical properties,” said Sirsi. “The mechanical properties of the shell dictate the acoustic response of a bubble, so our hypothesis was that different acoustic responses would be seen as the shell gets stiffer or more elastic.”
Preliminary results show a strong correlation between oxygen concentration and the acoustic bubble response, highlighting the potential use of microbubbles as oxygen sensors. This capability would have many benefits for medicine and imaging, including evaluating oxygen-deprived regions of tumors and in the brain.
———————– MORE MEETING INFORMATION ———————–
Main meeting website: https://acousticalsociety.org/asa-meetings/
Technical program: https://eventpilotadmin.com/web/planner.php?id=ASASPRING22
Press Room: https://acoustics.org/world-wide-press-room/
WORLDWIDE PRESS ROOM
In the coming weeks, ASA’s Worldwide Press Room will be updated with additional tips on dozens of newsworthy stories and with lay language papers, which are 300 to 500 word summaries of presentations written by scientists for a general audience and accompanied by photos, audio and video. You can visit the site during the meeting at https://acoustics.org/world-wide-press-room/.
We will grant free registration to credentialed journalists and professional freelance journalists. If you are a reporter and would like to attend, contact AIP Media Services at firstname.lastname@example.org. For urgent requests, staff at email@example.com can also help with setting up interviews and obtaining images, sound clips, or background information.
ABOUT THE ACOUSTICAL SOCIETY OF AMERICA
The Acoustical Society of America (ASA) is the premier international scientific society in acoustics devoted to the science and technology of sound. Its 7,000 members worldwide represent a broad spectrum of the study of acoustics. ASA publications include The Journal of the Acoustical Society of America (the world’s leading journal on acoustics), JASA Express Letters, Proceedings of Meetings on Acoustics, Acoustics Today magazine, books, and standards on acoustics. The society also holds two major scientific meetings each year. See https://acousticalsociety.org/.
Past Press Releases
As the number and size of offshore turbines increase, so does the possible disruption to aquatic life.Media Contact:Larry FrumAIP Media301firstname.lastname@example.org DENVER, May 26, 2022 – When an offshore wind farm pops up, there is a period of noisy but well-studied and...
Infrasound pulses from munitions plant explosions used to study gravity waves, atmospheric eventsMedia Contact: Larry Frum AIP Media 301-209-3090 email@example.com DENVER, May 25, 2022 – Infrasound waves can probe some of the most complex weather patterns hidden to normal...
Monitoring their soundscape can provide a long term, nonintrusive, inexpensive method for tracking the state of reefs around the worldMedia Contact:Larry FrumAIP Media301firstname.lastname@example.org DENVER, May 25, 2022 – A healthy coral reef is loud. Like a busy city, the...
Assistive listening devices can filter out noise from loudspeakers, improving clarityMedia Contact: Larry Frum AIP Media 301-209-3090 email@example.com DENVER, May 25, 2022 – People with hearing aids and other assistive listening devices often struggle at crowded events,...
Microphones on the rover capture, characterize sounds from red planet's atmosphereMedia Contact: Larry Frum AIP Media 301-209-3090 firstname.lastname@example.org DENVER, May 25, 2022 – Since NASA's Perseverance rover landed on Mars, its two microphones have recorded hours of audio...
Students less likely to engage with virtual networking events, increasing turnover, burnoutMedia Contact:Larry FrumAIP Media301email@example.com DENVER, May 24, 2022 – As in-person scientific meetings and gathering have been replaced by virtual meetings during...
Method avoids complications from using high-power lasers, extends to other medical applicationsMedia Contact:Larry FrumAIP Media301firstname.lastname@example.org DENVER, May 24, 2022 – Atherosclerosis, a buildup of plaque, can lead to heart disease, artery disease, and...
Aging effects on listening effort in cochlear-implant usersMedia Contact:Larry FrumAIP Media301email@example.com DENVER, May 24, 2022 – Degraded acoustic signals can make hearing difficult for anyone, but differences in cognitive abilities, age-related changes,...
Perception in context: How racialized identities impact speech perceptionMedia Contact:Larry FrumAIP Media301firstname.lastname@example.org DENVER, May 24, 2022 – Everyone has an accent. But the intelligibility of speech doesn't just depend on that accent; it also depends on...
Ultrasound-stimulated, drug-loaded bubbles for cancer therapyMedia Contact:Larry FrumAIP Media301email@example.com DENVER, May 24, 2022 – Microbubbles can assist with localized drug delivery in a patient's body by popping at a target site to create enhanced...