Ultrasound-stimulated, drug-loaded bubbles for cancer therapy
DENVER, May 24, 2022 – Microbubbles can assist with localized drug delivery in a patient’s body by popping at a target site to create enhanced permeability of tumor blood vessels. By temporarily increasing the porosity of the blood vessels, the microbubbles can create a means for coinjected anti-cancer drugs to preferentially leak into the tumor for treatment.
Naomi Matsuura, of the University of Toronto, and her team are adapting microbubbles to become more potent tools for cancer therapy. By shrinking the bubbles and directly loading them with anti-cancer drugs, the bubbles can lower the dose of free drug that is injected and diffuses into nontumor tissue in the body. This results in more targeted treatment and fewer side effects for the patient.
Matsuura will discuss her team’s results in her presentation, “Ultrasound-stimulated, drug-loaded bubbles for cancer therapy,” as part of the 182nd Meeting of the Acoustical Society of America at the Sheraton Denver Downtown Hotel. The session will take place May 24 at 11:30 a.m. Eastern U.S.
The team loaded taxanes, a commonly used anti-cancer drug, onto the bubbles. Because the drug is hydrophobic, it avoids water and sticks to the bubble easily, avoiding any leakage into the bloodstream or surrounding tissue until the bubble is stimulated by ultrasound.
They plan to extend the bubbles to carry other types of drugs as well, but the drug loading tends to be lower and less stable for hydrophilic materials.
“We are also modifying the pattern of the sound waves in a way that makes the anti-cancer drug more potent in comparison to a regular intravenous drug injection,” said Matsuura.
“If we can combine lower side effects from direct drug loading with a more potent effect of the drug by modifying systems that are already in place for patients, we have a chance to make an impact on the outcomes of cancer patients in a relatively short period of time.”
———————– MORE MEETING INFORMATION ———————–
Main meeting website: https://acousticalsociety.org/asa-meetings/
Technical program: https://eventpilotadmin.com/web/planner.php?id=ASASPRING22
Press Room: https://acoustics.org/world-wide-press-room/
WORLDWIDE PRESS ROOM
In the coming weeks, ASA’s Worldwide Press Room will be updated with additional tips on dozens of newsworthy stories and with lay language papers, which are 300 to 500 word summaries of presentations written by scientists for a general audience and accompanied by photos, audio and video. You can visit the site during the meeting at https://acoustics.org/world-wide-press-room/.
We will grant free registration to credentialed journalists and professional freelance journalists. If you are a reporter and would like to attend, contact AIP Media Services at firstname.lastname@example.org. For urgent requests, staff at email@example.com can also help with setting up interviews and obtaining images, sound clips, or background information.
ABOUT THE ACOUSTICAL SOCIETY OF AMERICA
The Acoustical Society of America (ASA) is the premier international scientific society in acoustics devoted to the science and technology of sound. Its 7,000 members worldwide represent a broad spectrum of the study of acoustics. ASA publications include The Journal of the Acoustical Society of America (the world’s leading journal on acoustics), JASA Express Letters, Proceedings of Meetings on Acoustics, Acoustics Today magazine, books, and standards on acoustics. The society also holds two major scientific meetings each year. See https://acousticalsociety.org/.
Past Press Releases
As the number and size of offshore turbines increase, so does the possible disruption to aquatic life.Media Contact:Larry FrumAIP Media301firstname.lastname@example.org DENVER, May 26, 2022 – When an offshore wind farm pops up, there is a period of noisy but well-studied and...
Infrasound pulses from munitions plant explosions used to study gravity waves, atmospheric eventsMedia Contact: Larry Frum AIP Media 301-209-3090 email@example.com DENVER, May 25, 2022 – Infrasound waves can probe some of the most complex weather patterns hidden to normal...
Monitoring their soundscape can provide a long term, nonintrusive, inexpensive method for tracking the state of reefs around the worldMedia Contact:Larry FrumAIP Media301firstname.lastname@example.org DENVER, May 25, 2022 – A healthy coral reef is loud. Like a busy city, the...
Assistive listening devices can filter out noise from loudspeakers, improving clarityMedia Contact: Larry Frum AIP Media 301-209-3090 email@example.com DENVER, May 25, 2022 – People with hearing aids and other assistive listening devices often struggle at crowded events,...
Microphones on the rover capture, characterize sounds from red planet's atmosphereMedia Contact: Larry Frum AIP Media 301-209-3090 firstname.lastname@example.org DENVER, May 25, 2022 – Since NASA's Perseverance rover landed on Mars, its two microphones have recorded hours of audio...
Students less likely to engage with virtual networking events, increasing turnover, burnoutMedia Contact:Larry FrumAIP Media301email@example.com DENVER, May 24, 2022 – As in-person scientific meetings and gathering have been replaced by virtual meetings during...
Method avoids complications from using high-power lasers, extends to other medical applicationsMedia Contact:Larry FrumAIP Media301firstname.lastname@example.org DENVER, May 24, 2022 – Atherosclerosis, a buildup of plaque, can lead to heart disease, artery disease, and...
Aging effects on listening effort in cochlear-implant usersMedia Contact:Larry FrumAIP Media301email@example.com DENVER, May 24, 2022 – Degraded acoustic signals can make hearing difficult for anyone, but differences in cognitive abilities, age-related changes,...
Perception in context: How racialized identities impact speech perceptionMedia Contact:Larry FrumAIP Media301firstname.lastname@example.org DENVER, May 24, 2022 – Everyone has an accent. But the intelligibility of speech doesn't just depend on that accent; it also depends on...
Modeling and optimizing sensor networks for a specific environment will help missions narrow in on shooter locationsMedia Contact:Larry FrumAIP Media301email@example.com DENVER, May 23, 2022 – During a gunshot, two sound events occur: the muzzle blast and the...